Fabclavine diversity in Xenorhabdus bacteria

• Sebastian L. Wenski,
• Harun Cimen,
• Natalie Berghaus,
• Sebastian W. Fuchs,
• Selcuk Hazir and
• Helge B. Bode

Beilstein J. Org. Chem. 2020, 16, 956–965, doi:10.3762/bjoc.16.84

• of fabclavines as major antibiotics in several entomopathogenic strains, our work lays the foundation for the rapid fabclavine identification and dereplication as the basis for future work of this widespread and bioactive SM class. Keywords: antibiotic; fabclavine; NRPS-PKS hybrid; secondary

• originally also contained the NRPS-PKS-hybrid genes (Figure 2) [22]. In contrast, the BGC of P. temperata is reduced to only harbor the homologous genes of fclC, fclD and fclE (Figure 2) [22]. X. innexi also harbors a fcl-like BGC, with protein identities of 68–90% compared to X. stockiae (Figure S1